Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 141-86-6, name is 2,6-Diaminopyridine. This compound has unique chemical properties. The synthetic route is as follows. 141-86-6
2,6-diaminopyridine (5. 0g, 46 mmol) and chloroacetaldehyde (50% wt. soln in water, 6.4 mL, 50 mmol) were dissolved in absolute EtOH (120 mL). The solution was heated at 75 C for 1 hour. The mixture was cooled and concentrated via rotavap. The residue was taken up in saturated NaHCO3 and EtOAc. The solution was extracted with EtOAc (3 times), dried over magnesium sulfate, and concentrated to give a brown solid. 4.85g isolated (80% yield). 1H NMR (CDC13) 5 4.48 (s, 2H), 6. 10. (dd, J = 7.2, 1.2 Hz, 1H), 7.10-7. 20 (m, 2H), 7.42 (d, J = 1.2 Hz, 1H), 7.65 (d, J = 1.2 Hz, 1H). MS Calcd.: 133; Found: 134 (M+H).
At the same time, in my other blogs, there are other synthetic methods of this type of compound,141-86-6, 2,6-Diaminopyridine, and friends who are interested can also refer to it.
Reference:
Patent; TAKEDA PHARMACEUTICAL COMPANY LIMITED; WO2005/44793; (2005); A2;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem