Related Products of 1480-64-4, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.1480-64-4, name is 3-Chloro-2-fluoropyridine, molecular formula is C5H3ClFN, molecular weight is 131.54, as common compound, the synthetic route is as follows.
Example 97 (4S,6S)-4-(5-((3-chloropyridin-2-yl)oxy)-2-fluorophenyl)-4-(fluoromethyl)-6-(trifluoromethyl)-5,6-dihydro-4H-1,3-oxazin-2-amine The title compound was synthesized using steps and procedures analogous to those described in Method M (Example 92) above, but using 3-chloro-2-fluoropyridine (Matrix) in step 5. MS m/z=422 [M]+. Calculated for C17H13ClF5N3O2: 421.75. 1H NMR (300 MHz, CHLOROFORM-d) ppm 2.19 (t, J=13.15 Hz, 1H) 2.69 (d, J=13.74 Hz, 1H) 4.18 (d, J=8.92 Hz, 3H) 4.34-4.58 (m, 1H) 4.61-4.86 (m, 1H) 6.98 (dd, J=7.38, 4.90 Hz, 1H) 7.12 (d, J=8.62 Hz, 2H) 7.30 (d, J=7.31 Hz, 2H) 7.76 (d, J=7.60 Hz, 1H) 8.00 (d, J=4.82 Hz, 1H).
The chemical industry reduces the impact on the environment during synthesis 1480-64-4, I believe this compound will play a more active role in future production and life.
Reference:
Patent; MINATTI, Ana Elena; LOW, Jonathan D.; ALLEN, Jennifer R.; CHEN, Jian; CHEN, Ning; CHENG, Yuan; JUDD, Ted; LIU, Qingyian; LOPEZ, Patricia; QIAN, Wenyuan; RUMFELT, Shannon; RZASA, Robert M.; TAMAYO, Nuria A.; XUE, Qiufen; YANG, Bryant; ZHONG, Wenge; US2014/249104; (2014); A1;,
Pyridine – Wikipedia,
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