Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 179687-79-7, name is 2-((2-Chloro-4-nitrophenoxy)methyl)pyridine. A new synthetic method of this compound is introduced below., HPLC of Formula: C12H9ClN2O3
The above product (13.2 g, 0.05 mol), iron powder (11.2 g, 0.2 mol) and 12 M HCl (4 mL, 0.05 mol) were added into 90% EtOH/H2O (200 mL) and the reaction mixture was stirred at 70 C for 1 h. The dark solution was filtered through a Celite pad. The filtrate was concentrated and the residual was dissolved in CH2Cl2 (200 mL). The organic layer was washed twice with water, and dried over anhydrous Na2SO4. The solvent was removed under reduced pressure to give 26 (10.9 g, 93%) as a light-yellow solid. Mp 90.9-91.8 C; MS-EI (m/z): 93, 142, 199, 234(M+); 1H NMR (DMSO-d6, delta): 4.95(s, 2H), 5.07(s, 2H), 6.45(dd, 1H), 6.65(d, 1H), 6.90(d, 1H), 7.35(t, 1H), 7.55(d, 1H), 7.85(t, 1H), 8.55(d, 1H).
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Reference:
Article; Mao, Yongjun; Zhu, Wenxiu; Kong, Xiaoguang; Wang, Zhen; Xie, Hua; Ding, Jian; Terrett, Nicholas Kenneth; Shen, Jingkang; Bioorganic and Medicinal Chemistry; vol. 21; 11; (2013); p. 3090 – 3104;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem