Reference of 188425-85-6, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 188425-85-6, name is 2-Chloro-N-(4′-chloro-[1,1′-biphenyl]-2-yl)nicotinamide. A new synthetic method of this compound is introduced below.
Add in a 100ml round bottom flask11-bromodecanoic acid 1 g (3.77 mmol),EDCI (0.72 g, 3.77 mmol) and HoBT (0.5 g, 3.77 mmol),Add 40 ml of dichloromethane to react for 15 min.Then, Boscalid {2-Chloro-N-(4′-chloro-[1,1′-biphenyl]-2-yl)nicotinamide} 1.24 g (3.6 mmol) was added. After 4 h of reaction, 1.5 g of 2-chloro-N-(4-chlorobiphenyl-2-yl)-N-(11-bromoundecyl)nicotinamide was obtained in a yield of 93%.
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,188425-85-6, its application will become more common.
Reference:
Patent; China Agricultural University; Tan Zhaohai; Wang Jiayao; Liu Xuelian; Tang Dachao; Xiao Yumei; Li Jiaqi; (46 pag.)CN109053801; (2018); A;,
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