Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 1065100-83-5, name is (1H-Pyrrolo[2,3-b]pyridin-3-yl)methanol. A new synthetic method of this compound is introduced below., category: pyridine-derivatives
(2) Add 7-azaindole-3-methanol to dichloromethane, heat to 50°C, add KMnO4 and mix well.The reaction was stirred for 3 h, filtered, evaporated under reduced pressure, and recrystallized to give 7-azaindole-3-carboxylic acid.In step (1), 7-azaindole and water are used in a molar ratio of 1 mol/L; 7-azaindole and tetramethylguanidine are used in a molar ratio of 2:5;The mass ratio of 7-azaindole to MFI zeolite is 6:7;The molar ratio of 7-azaindole to formaldehyde is 1:1.2;The microwave radiation power is 300W.The molar ratio of 7-azaindole-3-methanol to KMnO4 used in step (2) is 12:15.The yield of 7-azaindole-3-carboxylic acid produced was 94.3percent and the purity was 99.3percent.
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Reference:
Patent; Dongguan Lianzhou Knowledge Property Right Scheduled Operations Management Co., Ltd.; Chen Dongjin; (6 pag.)CN107903261; (2018); A;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem