Electric Literature of 63996-36-1 , The common heterocyclic compound, 63996-36-1, name is 2-(4-Bromophenyl)pyridine, molecular formula is C11H8BrN, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.
967 mg (4.10 mmoL) of Compound J, 759 mg (4.14 mmoL) of phenoxazine, 28 mg (0.123 mmoL) of Pd(OAc)2, 99 mg (0.492 mmoL) of P(t-Bu)3, and 569 mg (5.92 mmoL) of NaOt-Bu are dissolved in 40 mL of toluene, and the mixture is heated to 110 C., and the temperature is maintained until the reaction is terminated. When the reaction is terminated, the resultant is subjected to a work-up procedure and column chromatography to obtain Compound K (yield: 80%).
The synthetic route of 63996-36-1 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; Samsung Electronics Co., Ltd.; Yang, Hae Yeon; Son, Jun Mo; Ju, Won Jae; (34 pag.)KR101594129; (2016); B1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem