Adding a certain compound to certain chemical reactions, such as: 104830-06-0, 2-Amino-3-iodopyridine, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, Safety of 2-Amino-3-iodopyridine, blongs to pyridine-derivatives compound. Safety of 2-Amino-3-iodopyridine
General procedure: solution of acids 7, 9, 14, 21, 42-45 (1 mmol), EDC (0.19 g,1.1 mmol) and HOBt (0.13 g, 1 mmol) in anhydrous MeCN (10 mL)was stirred at r.t. for 30 min, then the appropriate amine (1 mmol)was added. The mixture was stirred at r.t. for 12 h in the case ofaliphatic amines and 36 h in the case of heteroaromatic and aromaticamines. After the solvent was removed under vacuum. Theresidue was dissolved in ethyl acetate (AcOEt) (20 mL) and washedsequentially with brine (2 x 5 mL), 10% citric acid (2 x 5 mL),saturated NaHCO3 aqueous solution (2 x 5 mL) and water(2 x 5 mL). The organic layer was dried over anhydrous Na2SO4 andevaporated under vacuum to give the title amides.
The synthetic route of 104830-06-0 has been constantly updated, and we look forward to future research findings.
Reference:
Article; Deplano, Alessandro; Morgillo, Carmine Marco; Demurtas, Monica; Bjoerklund, Emmelie; Cipriano, Mariateresa; Svensson, Mona; Hashemian, Sanaz; Smaldone, Giovanni; Pedone, Emilia; Luque, F. Javier; Cabiddu, Maria G.; Novellino, Ettore; Fowler, Christopher J.; Catalanotti, Bruno; Onnis, Valentina; European Journal of Medicinal Chemistry; vol. 136; (2017); p. 523 – 542;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem