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Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 947249-27-6, name is 2-Bromo-3-(difluoromethoxy)pyridine. A new synthetic method of this compound is introduced below., Application In Synthesis of 2-Bromo-3-(difluoromethoxy)pyridine

To a steel bomb were charged with 2-methoxyethanol (20ml), 2-bromo-3-(difluoromethoxy)pyridine (1.95g, 8.7 mmol), cone. aqueous NH4OH (28-30%, 5 ml, 79 mmol) and Cu2O (0.25 g,, 1.7 mmol). The reaction mixture was heated at 100 0C for 23 h, then cooled to 0 0C, and partitioned between mixture of EtOAc/aq. 3 N NaOHZH2O (40ml/10ml/30ml). The organic phase layer was collected, washed with saturated aqueous NaHCO3 solution (30ml), brine (40ml), dried (Na2SO^, and concentrated to produce 1.12 g of 3-(difiuoromethoxy)pyridin-2-amine which was carried forward without further purification: LCMS (m/z, MH+): 161.0, tR = 0.31min.

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Reference:
Patent; NOVARTIS AG; WO2009/115572; (2009); A2;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem