In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 3430-17-9, name is 2-Bromo-3-methylpyridine, the common compound, a new synthetic route is introduced below. Application In Synthesis of 2-Bromo-3-methylpyridine
a) Synthesis of 3-methyl-2-phenyl-pyridine To a stirred solution of 2-bromo-3-methylpyridine (30 g, 174 mmol) in dimethoxyethane (1.3 L) was added in one portion phenylboronic acid (42.5 g, 349 mmol) at room temperature, followed by an aqueous solution of sodium carbonate (3 M in water, 233 mL, 698 mmol). The mixture was degassed with argon for about 30 minutes, after which [1,1′-bis(diphenylphosphino)ferrocene]dichloropalladium(II), complex with dichloromethane (4.3 g, 5.0 mmol) was added, under argon. The reaction was stirred at 95 C. for 2 hours. The crude mixture was diluted with ethyl acetate and water and the organic layer was decanted. It was washed once with an aqueous solution of sodium hydroxide (0.5 M) and once with brine. The organic layer was collected, dried with sodium sulphate and concentrated in vacuo. The crude mixture was purified by flash chromatography on silica gel (eluent: ethyl acetate/cyclohexane 1:3). The title compound was obtained as a pale orange oil. 1H-NMR (CDCl3): delta=2.37 (s, 3H), 7.19 (dd, 1H), 7.37-7.41 (m, 2H), 7.42-7.49 (dd, 1H), 7.52-7.56 (m, 2H), 7.60 (d, 1H), 8.55 (d, 1H).
The synthetic route of 3430-17-9 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; SYNGENTA CROP PROTECTION, LLC; US2012/129875; (2012); A1;,
Pyridine – Wikipedia,
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