The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 14482-51-0, name is 2-Bromo-3,5-dichloropyridine. This compound has unique chemical properties. The synthetic route is as follows. Recommanded Product: 14482-51-0
To a solution of 56 g (0.246 mol) of 2-bromo-3,5-dichloropyridine in 500 mL of dry dimethylsulfoxide, were added 53 g (0.261 mol) of ethyl bromodifluoroacetate followed by 94 g (0.518 mol) of copper bronze (200 mesh). The suspension was stirred at 50 C for 5 hours. After cooling, a solution of 44 g (0.328 mol) of potassium monophosphate in 280 mL of water was added and stirred for 1 hour. The black mixture was filtered over a cake of Supercel, and the cake washed three times with 200 mL of ethyl acetate. The organic phases were collected, washed with brine and dried over magnesium sulfate. After evaporation of the solvent under vacuum 57.6 g of a brown oil were obtained. After purification by column chromatography over silica gel (heptane/ethyl acetate 9/1) 40 g (57%) of ethyl (3,5-dichloropyridin-2-yl)(difluoro)acetate (Int-5) were obtained as a yellow oil, (M+1) = 270, 19F-NMR (235MHz, CDCl3) delta (ppm): – 104.21 (CF2).
With the rapid development of chemical substances, we look forward to future research findings about 14482-51-0.
Reference:
Patent; Bayer CropScience AG; The designation of the inventor has not yet been filed; EP2606727; (2013); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem