Adding a certain compound to certain chemical reactions, such as: 1008304-85-5, 2-Chloro-6-methoxypyridin-4-amine, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, 1008304-85-5, blongs to pyridine-derivatives compound. Computed Properties of C6H7ClN2O
To a solution of 2-chloro-6-methoxypyridin-4-amine (790 mg, 5.00 mmol) in CH3CN (5 mL)was added water (5 mL) and conc. HCI (5 mL). Then a solution of NaNO2 (690 mg, 10.0mmol) in water (5 mL) was added dropwise at 0 C. After stirred at 0 C for 10 mm a solution of KI (1.66 g, 10.0 mmol) in water (5 mL) was added dropwise at 0C. The mixture was stirred at 0 C for 20 mm. Then, the reaction was quenched with sat. Na2S2O3 solution (50 mL). EtOAc (20 mL x 3) was added to extract desired compound. The combined organiclayers were washed with brine (20 mL), dried over Na2SO4 and concentrated. The residue was purified by column chromatography (PE)to give the title compound (1.1 g, yield 82%) as white solid.D490 1H NMR (300 MHz, CDCI3): O 7.26 (s, 1H), 7.07 (s, 1H), 3.91 (s, 3H).
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,1008304-85-5, its application will become more common.
Reference:
Patent; GLAXOSMITHKLINE INTELLECTUAL PROPERTY DEVELOPMENT LIMITED; GLAXOSMITHKLINE (CHINA) R & D COMPANY LIMITED; DING, Xiao; JIN, Yun; LIU, Qian; REN, Feng; SANG, Yingxia; STASI, Luigi Piero; WAN, Zehong; WANG, Hailong; XING, Weiqiang; ZHAN, Yang; ZHAO, Baowei; (573 pag.)WO2017/12576; (2017); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem