Application of 204378-41-6, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 204378-41-6, name is Methyl 6-chloro-4-methoxypicolinate. This compound has unique chemical properties. The synthetic route is as follows.
To a solution of methyl 6-chloro-4-methoxypicolinate 25 (600 mg, 2.98 mmol) and cyclopentylzinc bromide (12 mL of a 0.5 M solution in THF) in dioxane (10 mL) Pd(dppf)Cl2 (25 mg, 30 mol) was added. The mixture was stirred at 75°C for 18 h. The mixture was cooled the rt and the reaction was quenched by carefully adding water (20 mL). The mixture was filtered and the filtrate was extracted with EA (2×100 mL). The combined organic extracts were dried over MgSO4, filtered and concentrated. The crude product was purified by CC on silica gel eluting with heptane:EA 4:1 to give methyl 6-cyclopentyl-4-methoxypicolinate 30 (580 mg, ~80percent) as a pale yellow oil containing approx. 30percent of cyclopentyl 6-cyclopentyl-4-methoxypicolinate
While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 204378-41-6, Methyl 6-chloro-4-methoxypicolinate.
Reference:
Article; Bolli, Martin H.; Lescop, Cyrille; Birker, Magdalena; De Kanter, Ruben; Hess, Patrick; Kohl, Christopher; Nayler, Oliver; Rey, Markus; Sieber, Patrick; Velker, Joerg; Weller, Thomas; Steiner, Beat; European Journal of Medicinal Chemistry; vol. 115; (2016); p. 326 – 341;,
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