Related Products of 55934-02-6, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.55934-02-6, name is 2,3,4-Trichloropyridine, molecular formula is C5H2Cl3N, molecular weight is 182.4351, as common compound, the synthetic route is as follows.
The mixture of /er/-butyl /V-[(/er/-butoxy)carbonyl]-/V-(T-{3-hydroxy-l-[(4- methoxyphenyl )m ethyl ]- l//-pyrazolo[3,4-/>]pyrazin-6-yl }- 1 ,3-dihydrospiro[indene-2,4′- piperidin]-3-yl)carbamate (500 mg, 80% purity, 609 pmol, Intermediate BV), 2,3,4- trichloropyridine (133 mg, 730 pmol) and Cs2C03 (593 mg, 1.82 mmol) in DMF (5 mL) was stirred at 100 C for 24 hours. The mixture was diluted with H20 (20 mL), and extracted with EtOAc (20 mL x 2). The combined organic layers were washed with brine (20 mL), dried over anhydrous Na2S04, filtered and concentrated under reduced pressure to afford the residue. The residue was purified by column chromatography (petroleum ether / ethyl acetate = 1 : 0 ~ 3 : 1) to afford /er/-butyl /V-(l’-{3-[(2,3-dichloropyridin-4-yl)oxy]-l-[(4- methoxyphenyl )m ethyl ]- l //-pyrazolo[3,4-/>]pyrazin-6-yl }- 1 ,3-dihydrospiro[indene-2,4′- piperidin]-3-yl)carbamate (160 mg, 37% yield) as a yellow solid. LCMS m/z [M+H]+ = 702.2.
The chemical industry reduces the impact on the environment during synthesis 55934-02-6, I believe this compound will play a more active role in future production and life.
Reference:
Patent; RELAY THERAPEUTICS, INC.; D.E. SHAW RESEARCH, LLC; TAYLOR, Alexander, M.; LESCARBEAU, Andre; KELLEY, Elizabeth, H.; SHORTSLEEVES, Kelley, C.; WALTERS, W., Patrick; MURCKO, Mark, Andrew; MCLEAN, Thomas, H.; GUNAYDIN, Hakan; GIORDANETTO, Fabrizio; THERRIEN, Eric; (607 pag.)WO2019/183367; (2019); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem