In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 24100-18-3, name is 2-Bromo-3-methoxypyridine, the common compound, a new synthetic route is introduced below. SDS of cas: 24100-18-3
262 mL of conc. sulfuric acid was cooled down to -2C, and 262 mL of 90 % nitric acid was carefully added thereto. Subsequently, 65.3 g (corresponding to 0.347 mmol) of 2-bromo-3-methoxypyridine was carefully added thereto. After the reaction mixture was stirred in an ice bath for 10 minutes, the mixture was stirred at room temperature for 30 minutes, and then was heated to 55C and further stirred for 1.5 hours. After the reaction solution was cooled to room temperature, the reaction solution was poured little by little into crushed ice to generate precipitates. The precipitates were filtered and washed with water, and then dried over phosphorous pentoxide under reduced pressure, to obtain 55.7 g (corresponding to 0.239 mol) of 2-bromo-3-methoxy-6-nitropyridine (Fig. 3, Step 2).
The synthetic route of 24100-18-3 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; Nihon Medi-Physics Co., Ltd.; EP2213671; (2010); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem