In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 13466-43-8, name is 3-Bromopyridin-2(1H)-one, the common compound, a new synthetic route is introduced below. Recommanded Product: 13466-43-8
Methyl iodide (1.5 mL, 24.14 mmol) was added to a suspension of potassium carbonate (1668 mg, 12.07 mmol), TBAI (89 mg, 0.24 mmol) and 3-bromopyridin-2-ol (420 mg,2.4 14 mmol) in toluene (15 mL). The reaction mixture was heated to 40 C for 17 hours. The mixture was partitioned between DCM and water and the combined extracts dried (hydrophobic fit) and concentrated in vacuo. The crude product was purified by column chromatography on silica, eluted with 0-70% petrol/ethyl acetate to afford 3 -bromo- 1- methylpyridin-2(1H)-one, Intermediate 5 (390 mg, 86 %).?H NMR (400 MHz, DMSO-d6) & 3.50 (s, 3 H) 6.17 (t, J=7.07 Hz, 1 H) 7.78 (dd, J=6.82,1.77 Hz, 1 H) 7.90 (dd, J=7.33, 1.77 Hz, 1 H)
The synthetic route of 13466-43-8 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; TAKEDA PHARMACEUTICAL COMPANY LIMITED; TAKEDA CAMBRIDGE LIMITED; LIVERMORE, David; WHITE, Kathryn; CONGREVE, Miles; BROWN, Giles; O’BRIEN, Michael; WO2014/122474; (2014); A1;,
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