Reference of 72990-37-5, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 72990-37-5, name is 3-Chloroisonicotinaldehyde. A new synthetic method of this compound is introduced below.
General procedure: A solution of commercially available quinoline derivatives (1equiv.), p-toluenesulfonamide (1equiv.) and aldehyde (1equiv.) in toluene (1 M) was refluxed at 120C for 12h in a reaction tube under N2. After the mixture was cooled to room temperature, the solvent was removed under reduced pressure. Then the residue was purified by silica gel column chromatography to afford the vinyl quinoline derivatives.
At the same time, in my other blogs, there are other synthetic methods of this type of compound,72990-37-5, 3-Chloroisonicotinaldehyde, and friends who are interested can also refer to it.
Reference:
Article; Yue, Xuyi; Dhavale, Dhruva D.; Li, Junfeng; Luo, Zonghua; Liu, Jialu; Yang, Hao; Mach, Robert H.; Kotzbauer, Paul T.; Tu, Zhude; Bioorganic and Medicinal Chemistry Letters; vol. 28; 6; (2018); p. 1011 – 1019;,
Pyridine – Wikipedia,
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