Adding a certain compound to certain chemical reactions, such as: 55589-47-4, 3-Methylpicolinaldehyde, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, 55589-47-4, blongs to pyridine-derivatives compound. HPLC of Formula: C7H7NO
To a solution of X4-172-4 (1.0 g, 7.34 mmol), L-proline (338 mg, 2.94 mmol) and 3-methylpicolinaldehyde (1.07 g, 8.81 mmol) in MeOH (200.0 mL) was added methanamine aq. (8 mL, 40percent). The solution was stirred at room temperature overnight. The solvent was removed under reduce pressure and purified by column chromatography to give X4- 172-1 (1.4 g, 70.5 percent yield) as yellow solid. LCMS (Agilent LCMS 1200-6120, Column: Waters X-Bridge C18 (50 mm*4.6 mm*3.5 jim); Column Temperature: 40 °C; Flow Rate: 2.0 mL/min; Mobile Phase: from 90percent [(total 10mM AcONH4) water/CH3CN = 9/1 (v/v)] and 10percent [(total 10mM AcONH4) water/CH3CN = 1/9 (v/v)] to 10percent [(total 10mM AcONH4) water /CH3CN =9/1 (v/v)] and 90percent [(total 10mM AcONH4) water/CH3CN = 1/9 (v/v)] in 1.6 mm, then under this condition for 2.4 mm, finally changed to 90percent [(total 10mM AcONH4) water/CH3CN = 9/1 (v/v)] and 10percent [(total 10mM AcONH4) water/CH3CN = 1/9 (v/v)] in 0.1 mm and under this condition for 0.7 mm). Purity: 61.0 percent. Rt = 1.09 mm; MS Calcd.: 270.1; MS Found: 271.1 [M + H]t
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,55589-47-4, its application will become more common.
Reference:
Patent; X4 PHARMACEUTICALS, INC.; BOURQUE, Elyse Marie Josee; SKERLJ, Renato; (279 pag.)WO2017/223229; (2017); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem