Application of 87407-12-3 , The common heterocyclic compound, 87407-12-3, name is 3-(Trifluoromethyl)picolinic acid, molecular formula is C7H4F3NO2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.
A mixture of 3-trifluoromethyl-2-pyridine carboxylic acid (0.33 g, 1.6 mmol), (dimethylamino)-N,N-dimethyl(3H-[l,2,3]triazolo[4,5-]pyridin-3-yloxy)methaniminium hexafluorophosphate (i.e. HATU, 0.059 g, 1.6 mmol), and N,N-diisopropylethylamine (0.33 g, 2.6 mmol) were stirred in 10 mL dichloromethane. After 15 min, 2-[5-[3- (trifluoromethyl)-lH-pyrazol-l-yl]-2-pyrazinyl]benzenamine (i.e. the compound obtained in Example 3, Step C above) (0.4 g, 1.3 mmol) was added and the reaction was stirred at ambient temperature for approximately 16 h. The reaction mixture was then diluted with water and extracted with ethyl acetate. The combined organic extracts were washed with water, dried over Na2S04, evaporated under reduced pressure and then purified using silica gel column chromatography (20% ethyl acetate in petroleum ether as eluent) to yield 0.36 g of the title compound, a compound of the present invention. in NMR (400 MHz, dmso-d6) delta 12.20 (s, 1H), 9.31 (s, 1H), 9.05 (m, 2H), 8.91 (bs, 1H), 8.36 (m, 2H), 7.97 (d, 1H), 7.85 (m, 1H), 7.61 (t, 1H), 7.41 (t, 1H), 7.18 (d, 1H).
The synthetic route of 87407-12-3 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; E. I. DU PONT DE NEMOURS AND COMPANY; BEREZNAK, James, Francis; TAGGI, Andrew, Edmund; KAR, Moumita; REDDY, Ravisekhara, P.; CAMPBELL, Mathew, James; WO2014/172190; (2014); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem