As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 32710-65-9, name is 2,6-Dichloroisonicotinonitrile, molecular formula is C6H2Cl2N2, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below. Safety of 2,6-Dichloroisonicotinonitrile
Synthesis of 2-chloro-6-methoxy-pyridine-4-carbonitrile 25F A solution of compound 24 (2.0 g, 1 1.6 mmol) in methanol (20 mL) was added with sodium methoxyde (628 mg, 1 mol eq) and the mixture was heated at 60C for 6h. The reaction was cooled, evaporated to dryness and then water was added (300 mL). The aqueous phase was extracted with EtOAc (3×25 mL) and the recombined organic phases were dried over sodium sulfate and evaporated under reduced pressure to afford 25F as transparent viscous oil (1.95g, quantitative yield). FontWeight=”Bold” FontSize=”10″ HNMR (DMSO, 200 MHz) delta 3.80 (s, 3H), 7.17 (s, 1H), 7.90 (s, 1H).
With the rapid development of chemical substances, we look forward to future research findings about 32710-65-9.
Reference:
Patent; PHARMESTE S.R.L. IN LIQUIDATION; FRUTTAROLO, Francesca; PAVANI, Maria Giovanna; BENCIVENNI, Serena; GATTI, Raffaele; NAPOLETANO, Mauro; WO2014/135617; (2014); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem