Synthetic Route of 73870-24-3 ,Some common heterocyclic compound, 73870-24-3, molecular formula is C6H7Br2N, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.
General procedure: Compounds 20-26 (1 equiv.) were dissolved in DMF followed by the addition of potassium carbonate (1 – 3 equiv.) and the corresponding benzyl- or pyridinylderivate (1-2 equiv.). This mixture was allowed to stir at various temperatures and timespans, all of which are further specified at the corresponding compounds reported below. The crude product was then purified by either normal phase or reversed phase flash chromatography to yield compounds 30-36 and 40-46. The exact conditions of these purifications are reported below for each compound individually.
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,73870-24-3, its application will become more common.
Reference:
Patent; VIB VZW; UNIVERSITEIT ANTWERPEN; UNIVERSITEIT GENT; VANDENABEELE, Peter; VANDEN BERGHE, Tom; AUGUSTYNS, Koen; HOFMANS, Sam; VAN DER VEKEN, Pieter; DEVISSCHER, Lars; (66 pag.)WO2019/154795; (2019); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem