Synthetic Route of 165547-79-5, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.165547-79-5, name is 4-Chloro-3-nitro-2(1H)-pyridinone, molecular formula is C5H3ClN2O3, molecular weight is 174.54, as common compound, the synthetic route is as follows.
To a suspension of 4-chloro-3-nitro-2-pyridone (1.0 g, 5.7 mmol) and K2CO3 (1.6 g, 11.5 mmol) in DMA (5 mL) was added Mel (0.72 mL, 11.5 mmol). The rxn mixture was heated to 45C and stirred for 1h. It was quenched with H2O, acidified to pH 5 with a 25% aq. soln. of HCI and extracted with EtOAc (3x). The combined org. phases were washed with brine, dried over MgSCh and concentrated in vacuo. LC-MS: tR=0.60 min ; [M+H]+: 189.15 (0934) 1H NMR (400 MHz, DMSO-d6)5: 8.10 (d, J = 7.4 Hz, 1 H), 6.70 (d, J = 7.4 Hz, 1 H), 3.55 (s, 3 H)
Statistics shows that 165547-79-5 is playing an increasingly important role. we look forward to future research findings about 4-Chloro-3-nitro-2(1H)-pyridinone.
Reference:
Patent; IDORSIA PHARMACEUTICALS LTD; FROIDEVAUX, Sylvie; HUBLER, Francis; MURPHY, Mark; RENNEBERG, Dorte; STAMM, Simon; (188 pag.)WO2019/141803; (2019); A1;,
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