Related Products of 1083197-78-7, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 1083197-78-7, name is 4-(Trifluoromethyl)nicotinaldehyde. A new synthetic method of this compound is introduced below.
4-(trifluoromethyl)nicotinaldehyde was added to a solution of l,2-diamino-4,5- difluoropyridinium 2,4,6-trimethylbenzenesulfonate (47-4; 0.2 g, 0.000579 mol) in ethanol (20 mL) while stirring, followed by the addition of l,8-diazabicyclo[5.4.0]undec- 7-ene. The reaction mixture was stirred for 12 h at RT. It was then concentrated under vacuum, diluted with water (50 mL) and extracted with ethyl acetate (2 x 50 mL). The collected organic parts were concentrated under vacuum to afford the crude product, which was purified by silica gel column chromatography to afford the title compounds. 1H NMR (400 MHz, DMSO) delta 8.20 (s, 1 H), 9.09-9.06 (m, 1 H), 9.03-9.02 (d, J = 4 Hz, 1 H), 7.99-7.77 (d, J = 8 Hz, 1 H), 7.61-7.55 (m, 1 H). HPLC purity- 99.13%, MS (M+1): 301.1.
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,1083197-78-7, its application will become more common.
Reference:
Patent; MERCK SHARP & DOHME CORP.; BENNETT, D. Jonathan; CAI, Jaiqiang; CARSWELL, Emma; COOKE, Andrew; HOYT, Scott, B.; LONDON, Clare; MACLEAN, John; RATCLIFFE, Paul; TAYLOR, Jerry Andrew; XIONG, Yusheng; SAMANTA, Swapan Kumar; KULKARNI, Bheemashankar, A.; WO2013/43520; (2013); A1;,
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