As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 183208-35-7, name is 5-Bromo-1H-pyrrolo[2,3-b]pyridine, molecular formula is C7H5BrN2, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below. Computed Properties of C7H5BrN2
Step-i: 5-Bromo-3-iodo-1H-pyrrolo[2.3-b ]pyridinePCT/IB2013/0553885-Bromo-1H-pyrrolo[2,3-b]pyridine (5 g, 25 mmol) was dissolved in anhydrous acetone (7510 ml) and added N-iodo succinimide (6.18 g, 27.5 mmol) under nitrogen atmosphere and stirredat RT for 2 h. The reaction was monitored by TLC (10% Ethyl acetate in hexane). Thereaction mixture was cooled to RT and filtered, washed with cold acetone (50 ml) and driedunder vacuum to afford 7.05 g (87% yield) of 5-bromo-3-iodo-1H-pyrrolo[2,3-b]pyridine.MS: m/z = 324.6 (M+1); HPLC: 91.11% in method B.
With the rapid development of chemical substances, we look forward to future research findings about 183208-35-7.
Reference:
Patent; AURIGENE DISCOVERY TECHNOLOGIES LIMITED; UM PHARMAUJI SDN. BHD; GUMMADI, Venkateshwar, Rao; HOSAHALLI, Subramanya; NANDURI, Srinivas; AGGUNDA RENUKAPPA, Girish; WO2014/6554; (2014); A1;,
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