Share a compound : 5-Bromo-2,3-dihydro-1H-pyrrolo[2,3-b]pyridine

With the rapid development of chemical substances, we look forward to future research findings about 115170-40-6.

As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 115170-40-6, name is 5-Bromo-2,3-dihydro-1H-pyrrolo[2,3-b]pyridine, molecular formula is C7H7BrN2, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below. Application In Synthesis of 5-Bromo-2,3-dihydro-1H-pyrrolo[2,3-b]pyridine

A mixture of la (0.35 g, 1.76 mmol), 3-methoxybenzenesulfonyl chloride (0.37 mL, 2.64 mmol), and pyridine (3 mL) was refluxed overnight. The reaction was quenched with water and the mixture was extracted with ethyl acetate (30 ml x 3). The organic layer was collected, dried over anhydrous MgS04, and concentrated in vacuo to yield a brown residue, which was purified by a flash column over silica gel (ethyl acetate : n-hexane = 1 : 1 , Rf = 0.73) to afford 2c (0.56g, 86.17%) as a yellow solid. ‘H-NMR (500MHZ, CDCI3): delta 3.04 (t, /= 8.5 Hz, 2H), 3.84 (s, 3H), 4.07 (t, /= 8.5 Hz, 2H), 7.11 (dd, /= 2.5, 9.0 Hz, 1H), 7.38 (t, /= 8.0 Hz, 1H), 7.46 (s, 1H), 7.62 (dd, /= 1.5, 8.0 Hz, 1H), 7.65 (s, 1H), 8.19 (s, 1H).

With the rapid development of chemical substances, we look forward to future research findings about 115170-40-6.

Reference:
Patent; YEN, Yun; TAIPEI MEDICAL UNIVERSITY; NATIONAL HEALTH RESEARCH INSTITUTES; LIOU, Jing-Ping; CHANG, Jang-Yang; WANG, Jia-Yi; WO2015/157504; (2015); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem