Adding a certain compound to certain chemical reactions, such as: 74115-12-1, 5-Chloro-3-hydroxypyridine, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, 74115-12-1, blongs to pyridine-derivatives compound. Product Details of 74115-12-1
EXAMPLE 19a Production of 3-(5-chloro-3-pyridyloxy)-4,5,6,7-tetrahydro-4-oxobenzo[c]thiophene-1-carboxylic Acid Ethyl Ester: A mixture of the compound (20.0 g, 66.14 mmol) obtained in Example 3a, 3-chloro-5-hydroxypyridine (9.43 g, 72.76 mmol, 1.1 eq), anhydrous potassium carbonate (45.7 g, 330.7 mmol, 5.0 eq), toluene (240 ml), and ethyl acetate (160 ml) was stirred at reflux for 3 hours. The reaction solution was cooled to room temperature, mixed with water (200 ml) and 2-butanone (200 ml), and stirred foe 30 minutes. After standing followed by separation, the organic layer was washed successively with water (200 ml) and an aqueous, saturated solution of sodium chloride (200 ml). The organic layer was concentrated under reduced pressure to dryness to obtain the title compound (21.81 g, 93.7% yield). 1H NMR (300 MHz, CDCl3) delta: 1.33 (3H, t, J=7.1 Hz), 2.07 (2H, t, J=6.3 Hz), 2.53 (2H, t, J=6.3 Hz), 3.24 (2H, t, J=6.3 Hz), 4.30 (2H, q, J=7.1 Hz), 7.50-8.46 (4H, m)
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,74115-12-1, its application will become more common.
Reference:
Patent; Yasuma, Tsuneo; Mori, Akira; Kawase, Masahiro; Takizawa, Masayuki; Miki, Shokyo; Takeda, Mitsuhiro; US2003/158245; (2003); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem