Synthetic Route of 20511-12-0 , The common heterocyclic compound, 20511-12-0, name is 5-Iodopyridin-2-amine, molecular formula is C5H5IN2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.
Bromine (3ml) was added dropwise to a solution of 2-amino-5-iodo-pyridine (5g, 20mmol) in 48% hydrobromic acid in water (10ml). AIL ice bath was used to cool the system. Sodium nitrite (3.4 g in 5ml of water) was then added dropwise so that the temperature does not go above 15C. After the addition was complete, sodium hydroxide (16g) in water (40ml) was added. Brown solid precipitated and was extracted with DCM (50ml). The DCM extract was washed with water, brine, dried over MgS04 and evaporated in vacuo to give 2-bromo-5-iodo-pyridine (4.4g, 78%).
The synthetic route of 20511-12-0 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; F2G LTD; WO2005/92304; (2005); A2;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem