Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 1003-68-5, name is 5-Methylpyridin-2(1H)-one. A new synthetic method of this compound is introduced below., Recommanded Product: 5-Methylpyridin-2(1H)-one
To a 25 mL round bottom flask was added 0.10 g (1 mmol, 1 quiv.) Of compound 3, 0.17 g (1 mmol, 1 quiv.) Of p-bromobenzaldehyde, 1.4 g (10 mmol, 10 equiv.) Of K2CO3,0.05 g (0.26 mmol, 0.26 equiv.) CuI,5 mL of DMF as solvent,Reflux stirring reaction 1h,TLC, the reaction was completed, the mixture was cooled, the mixture was extracted with 30 mL of water and extracted with 3 x 20 mL of ethyl acetate. The organic layer was dried over anhydrous sodium sulfate, spin dried and separated by 300 mesh silica gel column chromatography. Eluent petroleum ether: ethyl acetate = : 3 (v / v) to give pale yellow solid: Compound 4.
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Reference:
Patent; Sichuan Univeristy; Yi, Shufan; Li, Yong; Cao, Tingting; Yang, Ziyao; (17 pag.)CN106083702; (2016); A;,
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