With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.52605-96-6, name is 2-Chloro-3-methoxypyridine, molecular formula is C6H6ClNO, molecular weight is 143.57, as common compound, the synthetic route is as follows.Computed Properties of C6H6ClNO
A three-necked flask was charged with Compound 1 (5.58 g, 39.0 mmol), N, N-dimethylformamide (60 mL) and sodium methoxide (6.20 g, 115.0 mmol); the reaction was stirred overnight at 60 C.The reaction was cooled to room temperature, water (120 mL) was added and extracted with ethyl acetate (80 mL x 3); the organic phases were combined, washed with water (100 mL x 2) and saturated brine (100 mL), dried over sodium sulfate, . The filtrate was spin-dried to give a yellow liquid, compound 2 (4.0 g, 28.9 mmol, 74%).
At the same time, in my other blogs, there are other synthetic methods of this type of compound,52605-96-6, 2-Chloro-3-methoxypyridine, and friends who are interested can also refer to it.
Reference:
Patent; Kanghua (Shanghai) Drug Discovery Co., Ltd.; Ma Jingxiang; (5 pag.)CN107286084; (2017); A;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem