Reference of 53937-02-3, Adding some certain compound to certain chemical reactions, such as: 53937-02-3, name is 4-Benzyloxy-2-(1H)-pyridone,molecular formula is C12H11NO2, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 53937-02-3.
A solution of 4-benzyloxy-2(1H)-pyridone (274 mg, 1.36 mmol), the iodide of preparation 10 (567 mg, 1.36 mmol), copper iodide (53 mg, 0.27 mmol), potassium carbonate (376 mg, 2.72 mmol) and rac-trans-N,N’-dimethyl cyclohexane-1,2-diamine (86 ml, 0.54 mmol) in 1,4-dioxan (10 ml) was degassed via a nitrogen/vacuum cycle. The resulting mixture was then heated to 100 C. under a nitrogen atmosphere for 16 hours. The reaction was cooled to room temperature and concentrated in vacuo. The residue was treated with 0.880NH3/H2O (10 ml, 1:1 v/v ratio) and stirred for 15 min. The resulting solid was filtered off and dried in vacuo giving the title compound (Prep. 11a/Ex. 23a) as a brown solid 550 mg (82%). 1H NMR (400 MHz, CDCl3) delta ppm 1.13 (t, 3H), 1.43 (s, 9H). 2.09-2.25 (m, 2H), 3.12-3.30 (m, 2H), 3.31 (t, 1H), 3.40 (q, 1H), 3.65 (q, 2H), 4.60-4.77 (m, 1H), 5.01 (s, 2H), 6.00-6.01 (m, 2H), 6.40 (d, 1H), 7.18 (d, 1H), 7.30-7.41 (m, 5H), 7.48 (dd, 1H), 8.03 (d, 1H). LRMS m/z (ESI) 491 [MH+].
According to the analysis of related databases, 53937-02-3, the application of this compound in the production field has become more and more popular.
Reference:
Patent; Pfizer Inc; US2008/85884; (2008); A1;,
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