5470-18-8 ,Some common heterocyclic compound, 5470-18-8, molecular formula is C5H3ClN2O2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.
Methylamine (33% in EtOH) (1 10 mL, 883 mmol) was placed in a 500 mL three necked round bottom flask. It was cooled to 0 C using ice bath. 2-chloro-3-nitropyridine (20 g, 126 mmol) was added to the above solution in portions as this is an exothermic reaction. After the addition was complete the reaction mixture was stirred for 2 h at 0 C and later 1 h at room temperature. Solvent was concentrated and residue was taken in 500 mL of water and extracted with EtOAc 3 x 150 mL. Combine organic layer was dried over Na2SC”4, filtered and concentrated to give a bright orangish yellow solid(19 g , 98.5%).
According to the analysis of related databases, 5470-18-8, the application of this compound in the production field has become more and more popular.
Reference:
Patent; UNIVERSAL DISPLAY CORPORATION; WU, Yonggang; XIA, Chuanjun; FIORDELISO, James; LAYEK, Suman; ALLEYNE, Bert; DYATKIN, Alexey, Borisovich; ANSARI, Scott; BEERS, Scott; BARRON, Ed; BROOKS, Jason; WO2012/121936; (2012); A2;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem