Synthetic Route of 5470-70-2, Adding some certain compound to certain chemical reactions, such as: 5470-70-2, name is Methyl 6-methylnicotinate,molecular formula is C8H9NO2, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 5470-70-2.
A solution of methyl 6-methylnicotinate (0.5 g, 3.3 mmol) in THF (16 mL) at 0¡ã C. was treated dropwise with lithium aluminum hydride in THF (6.6 mL, 1 M), stirred at 0¡ã C. for 1.5 hours, treated with ethyl acetate (3 mL), stirred at 25¡ã C. The reaction was partitioned between ethyl acetate and saturated NaHCO3, and the organic phase was washed with brine and dried over MgSO4, filtered and concentrated. A solution of the residue (0.395 g) in dichloromethane (16 mL) was treated with MnO2 (2 g), stirred at 25¡ã C. for 68 hours, filtered through celite.(R). to give the title compound (0.326 g, 80percent yield), which was used without further purification.
According to the analysis of related databases, 5470-70-2, the application of this compound in the production field has become more and more popular.
Reference:
Patent; DeGoey, David A.; Flentge, Charles A.; Flosi, William J.; Grampovnik, David J.; Kempf, Dale J.; Klein, Larry L.; US2005/131017; (2005); A1;,
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