While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 59020-10-9, 3-(Tributylstannyl)pyridine.
Reference of 59020-10-9, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 59020-10-9, name is 3-(Tributylstannyl)pyridine. This compound has unique chemical properties. The synthetic route is as follows.
Pd(PPh3)2Cl2 (3.84 mg, 0.0054mmol) was added to a solution of ((S)- 1-(N1^- Bromo-benzyl)-N’-[(S)-3-hydroxy-3-((lS,2R)-2-hydroxy-indan-l-ylcarbamoyl)-4- phenyl-butyl]-hydrazinocarbonyl}-2,2-dimethyl-propyl)-carbamic acid methyl ester (22) (75 mg, 0.108 mmol), 3-(l,l,l-tri-?-butylstannyl)pyridine (159 mg, 0.431 mmol) and CuO (8.6 mg, 0.108 mmol) in DMF (2.0 mL) and stirred in a heavy-walled Smith process EPO vial at 120 0C 50 min in the microwave cavity. The mixture was diluted with CH2Cl2 (20.0 mL) and washed with aq. saturated NaHCO3 (3 x 15.0 mL). The organic layer was dried (MgSO4) and evaporated. The residue was re-dissolved in CH3CN (50.0 mL) and washed with isohexane (3 x 20.0 mL). The acetonitrile phase was evaporated and the crude product was purified using RP-LC-MS (45 min gradient of 15-70% CH3CN in 0.05% aqueous formic acid) which gave the title product (23.1 mg, 31%) as a white solid. MS (ESI+): m/z: 694 (M+);1H NMR (CD3OD 400 MHz): delta 8.66 (m, IH), 8.45 (m, IH), 8.00 (m, IH), 7.52-7.44 (m, 6H), 7.30-7.04 (m, 9H), 5.04 (m, IH), 4.24 (m, IH), 3.82 (m, 2H), 3.68 (s, IH)5 3.60 (s, 3H), 3.10-2.78 (m, 6H), 2.62 (s, IH), 2.20 (m, IH), 1.96 (m, IH), 0.78 (s, 9H); 13C NMR (CD3OD, 100 MHz): delta 176.9, 171.1, 157.8, 147.8, 147.0, 141.3, 140.3, 137.0, 136.8, 135.2, 130.5, 130.0, 127.6, 126.8, 126.5, 126.3, 124.9, 124.1, 78.7, 72.5, 61.9, 61.7, 57.2, 53.6, 51.5, 39.6, 34.3, 33.5, 28.3, 25.7
While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 59020-10-9, 3-(Tributylstannyl)pyridine.
Reference:
Patent; MEDIVIR AB; WO2006/84688; (2006); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem