Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 1190320-33-2, name is 6-Fluoro-1H-pyrrolo[3,2-b]pyridine. This compound has unique chemical properties. The synthetic route is as follows. HPLC of Formula: C7H5FN2
To a solution of 6-Fluoro-lH-pyrrolo[3,2-b]pyridine (CAS: 1190320-33-2 , 6.5 g, 47.74 mmol) in dry DMF (65 mL), was added NaH(3.82 g, 95.49 mmol) at 0C in portions, then the reaction mixture was stirred at room temperature for lh. Methyl iodide (5.30 mL, 95.49 mmol) was added at 0C, then stirred at room temperature for 2h. After the consumption of starting material, reaction mixture was cooled to 0C, added water and extracted with ethyl acetate (2X 100 mL)). The combined organic layers were washed with brine, dried over sodium sulphate and evaporated under reduced pressure to get crude. Crude was purified by column chromatography (230/400 mesh, 30% ethyl acetate in pet-ether) to get desire compound Xllla as white solid (6 g, 85%). LC_MS Calc. for C8H7FN2 150.16; obtained: 151.11H NMR (400 MHz, DMSO-D6): delta 8.33 (s, 1H), 7.89-7.86 (m, 1H), 7.64 (d, 1H, J=2.8 Hz), 6.58 (s, 1H), 3.80 (s, 3H).
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Reference:
Patent; BUGWORKS RESEARCH INDIA PVT LTD; PEER MOHAMED, Shahul Hameed; BHARATHAM, Nagakumar; KATAGIHALLIMATH, Nainesh; SHARMA, Sreevalli; NANDISHAIAH, Radha; (113 pag.)WO2017/199265; (2017); A1;,
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