609-70-1, In the chemical reaction process,reaction time,type of solvent,can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product.An updated downstream synthesis route of 609-70-1 as follows.
Step 1 Methyl 4-hydroxynicotinate 4-Hydroxynicotinic acid (5.00 g, 35.94 mmol) was dissolved in methanol (50.00 mL), added with sulfuric acid (18M, 100.00 uL), and then stirred at 70 C. under nitrogen atmosphere for 12 hours. After the reaction mixture was concentrated, the residue was dissolved in dichloromethane (50.00 mL) and the system was adjusted to pH=8 with saturated sodium bicarbonate solution. A white solid was slowly precipitated and filtered to give methyl 4-hydroxynicotinate (a white solid, 3.0 g, crude product). 1H NMR (400 MHz, CDCl3) 8.27 (s, 1H), 7.67 (d, J=6.8 Hz, 1H), 6.21 (d, J=7.0 Hz, 1H), 3.69 (s, 3H).
The chemical industry reduces the impact on the environment during synthesis 609-70-1, I believe this compound will play a more active role in future production and life.
Reference:
Patent; Heilongjiang Zhenbaodao Pharmaceutical Co., Ltd.; MEDSHINE DISCOVERY INC.; HE, Haiying; JIANG, Zhigan; XIA, Jianhua; WANG, Jing; HAN, Lixia; LAN, Lihong; ZHOU, Hui; LAI, Kunmin; CHEN, Shuhui; US2018/346438; (2018); A1;,
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