Adding a certain compound to certain chemical reactions, such as: 626-64-2, Pyridin-4-ol, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, 626-64-2, blongs to pyridine-derivatives compound. 626-64-2
To a mixture of 4-hydroxypyridine (0.953 g, 10 mmol) and DBU (2.3 mL, 15 mmol, 1.5 equiv) in DMF (20 mL) was added p-methoxybenzyl chloride (2.0 mL, 15 mmol, 1.5 equiv). The reaction mixture was stirred at 66 C for 4 h. After cooling to the room temperature, the solvent was removed under reduced pressure. The residue was partitioned between CHCl3 and H2O. The organic layer was washed with saturated aqueous NaCl solution, dried over anhydrous MgSO4, and then concentrated under reduced pressure. The residue was purified by flash column chromatography (CHCl3/MeOH=9:1, Rf=0.30) to give the white solid (11, 1.89 g, 8.8 mmol, 88%). Mp 166-168 C (from column); 1H NMR (CDCl3, 400 MHz) delta 7.35 (d, 2H, J=7.6 Hz, CH), 7.12 (d, 2H, J=8.8 Hz, CH), 6.88 (d, 2H, J=8.8 Hz, CH), 6.31 (d, 2H, J=7.6 Hz, CH), 4.87 (s, 2H, CH2), 3.77 (s, 3H, CH3); 13C NMR (CDCl3, 100 MHz) delta 178.8, 159.9, 139.9 (CH), 129.1 (CH), 126.7, 118.5 (CH), 114.5 (CH), 59.5 (CH2), 55.3 (CH3).
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,626-64-2, its application will become more common.
Reference:
Article; Cheng, Chien; Shih, Yu-Chiao; Chen, Hui-Ting; Chien, Tun-Cheng; Tetrahedron; vol. 69; 4; (2013); p. 1387 – 1396;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem