The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 641569-94-0, name is 4-Methyl-3-((4-(pyridin-3-yl)pyrimidin-2-yl)amino)benzoic acid. This compound has unique chemical properties. The synthetic route is as follows. 641569-94-0
Add 4-Methyl-3-[[4- (3-pyridinyl) -2-pyrimidinyl] amino] benzoic acid (107.2 mg, 0.35 mmol), add thionyl chloride (0.50 mL), DMF (3 drops) and bring to room temperature The mixture was stirred for 17 hours. The solution was then concentrated to dryness.After that, THF (5.0 mL) was added and 3-Bromo-4- (4-methyl-piperazin-1-ylmethyl) -phenylamine (C) (82.4 mg, 0.29 mmol),DMAP (1.2 mg, 0.01 mmol),N, N-Diisopropylethylamine (60.6 muL, 0.35 mmol) was added and the mixture was stirred at room temperature for 2.5 hours. Add water and ethyl acetate,After washing with saturated aqueous sodium hydrogen carbonate solution, the solvent was distilled off. The obtained residue is subjected to silica gel column chromatographyPurification by (chloroform: methanol = 5: 1) gave IMT-5 precursor (43.0 mg, 0.075 mmol, 25%, white solid)
Statistics shows that 641569-94-0 is playing an increasingly important role. we look forward to future research findings about 4-Methyl-3-((4-(pyridin-3-yl)pyrimidin-2-yl)amino)benzoic acid.
Reference:
Patent; Kyoto University; Arkray Corporation; Saji, Hideo; Kimura, Hiroyuki; Matsuda, Hirokazu; Soma, Tasukukei; Nakanishi, Shuichi; (26 pag.)JP2019/64987; (2019); A;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem