Electric Literature of 6419-36-9, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 6419-36-9, name is 2-(Pyridin-3-yl)acetic acid hydrochloride, molecular formula is C7H8ClNO2, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.
The 3-pyridine acetic acid hydrochloride obtained in step (4), phosphorous acid and chlorobenzene were added to a three – necked flask, and the amount ratio of the of the 3-pyridine acetic acid hydrochloride to phosphorous acid was 1:25 . The amount of chlorobenzene used was calculated according to the addition of 0.1 moles of 3-pyridine acetic acid hydrochloride per 100 mL of chlorobenzene. Reaction was stirr heated to reflux, dropping addition phosphorus trichloride, according to the ratio of the amount of 3-pyridine acetic acid hydrochloride and phosphorus trichloride was 1: 3 drop of phosphorus trichloride. After completion of the dropwise addition, the mixture was further refluxed for 7.5 hours, cooled to room temperature, and dumped chlorobenzene. The concentrated hydrochloric acid having a mass fraction of 37.5% and water was added to the residue , and 100 mL of concentrated hydrochloric acid and 50 mL of water were added per 100 mL of chlorobenzene, and refluxed for 7 hours. The activated charcoal was decolorized and filtered. The filtrate was concentrated to dryness under reduced pressure. The residue was added to absolute ethanol and 100 mL of anhydrous ethanol was added per 100 mL of chlorobenzene, precipitated large solid precipitation, and crushed into a powder. filtered, filter cake recrystallization with water, then drying at 80 C, to obtain white solid that is risedronic acid, the based on amount calculation of 3- Pyridine carbonyl chloride hydrochloride , the yield of risedronic acid was 60%.
According to the analysis of related databases, 6419-36-9, the application of this compound in the production field has become more and more popular.
Reference:
Patent; Luohe Medical College; Ding Sujun; He Xinlei; Zhou Haiyang; Zhang Huifen; Li Pinai; (11 pag.)CN104628770; (2017); B;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem