In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 74115-13-2, name is 5-Bromo-3-pyridinol, the common compound, a new synthetic route is introduced below. 74115-13-2
Caesium carbonate (6.52 g, 20.0 mmol) was added to a stirred solution of 5-bromopyridin-3-ol (1.74 g, 10 mmol) in DMF (25 mL). The reaction mixture was stirred at 60 C for 30 minutes, then benzyl bromide (2.05 g, 1.43 mL, 12 mmol) was added. The reaction mixture was stirred at 60 C for 2 hours. The reaction mixture was cooled to room temperature and partitioned between diethyl ether (100 mL) and water (50 mL). The organic phase was separated, dried and evaporated. The residue was purified by chromatography on silica gel eluting with dichloromethane to give 3-(benzyloxy)-5- bromopyridine (1.17 g, 4.43 mmol, 44.3% yield) as an orange solid. LCMS (2 min, Formic Acid): Rt = 1.15 min, MH+ = 264/266
The synthetic route of 74115-13-2 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; GLAXOSMITHKLINE LLC; AMANS, Dominique; BAMBOROUGH, Paul; BIT, Rino, Antonio; BROWN, John, Alexander; CAMPBELL, Matthew; LINDON, Matthew, John; SHIPLEY, Tracy, Jane; THEODOULOU, Natalie, Hope; WELLAWAY, Christopher, Roland; WESTAWAY, Susan, Marie; WO2014/78257; (2014); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem