Synthetic Route of 79055-62-2, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 79055-62-2, name is 2-Chloro-5-methylpyridin-4-amine. This compound has unique chemical properties. The synthetic route is as follows.
CuBr2 (984 mg, 4.4 mmol, 2.0 equiv. ) and tert-butylnitrite (0.5 mL) were mixed in acetonitrile (4 mL). The resulting mixture was heated at 65 C for 20 minutes and 4-amino-2-chloro-5- methylpyridine (320 mg, 2.2 mmol, 1.0 equivalent) was then added and the resulting mixture was stirred for 10 minutes at 65 C. The reaction mixture was poured on water and extracted with ethyl acetate. The organic layer was washed with NH40H until no blue color was observed in the aqueous layer. After washing with water, the organic extract was dried over Na2S04 and the solvent was removed under reduced pressure. The crude residue was purified by preparative TLC on Si02 (dichloromethane) to afford the title compound as a colorless oil (170 mg, 0.8 mmol, HPLC Rt 6.709 min, FIA ES+ 205.9, 207.9, ES- 205.9).
According to the analysis of related databases, 79055-62-2, the application of this compound in the production field has become more and more popular.
Reference:
Patent; VERTEX PHARMACEUTICALS, INCORPORATED; WO2005/100342; (2005); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem