With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.81167-60-4, name is 4-(tert-Butyl)-2-chloropyridine, molecular formula is C9H12ClN, molecular weight is 169.6513, as common compound, the synthetic route is as follows.81167-60-4
2-Chloro-4-tert-butylpyridine (19.92 grams, 0.1 174 mol), 3- chlorophenylboronic acid (20.17 grams, 0.1290 mol), water (332 ml.), potassium carbonate (45.65 grams, 0.3303 mol), and monoglyme (332 ml.) were combined and sparged with nitrogen 45 minutes. Tetrakistriphenylphosphinepalladium(O) (4.98 grams, 5.746 mmol) was quickly added and the mixture was heated to reflux overnight. The mixture was concentrated by rotary evaporation to remove the monoglyme. Dichloromethane (“DCM”) was added and extracted with water several times then preabsorbed to solid media. Silica chromatography with DCM and hexanes was used to purify the product which was concentrated to 27 grams of yellow oil.
Statistics shows that 81167-60-4 is playing an increasingly important role. we look forward to future research findings about 4-(tert-Butyl)-2-chloropyridine.
Reference:
Patent; E. I. DU PONT DE NEMOURS AND COMPANY; HERRON, Norman; GAO, Weiying; WO2013/142634; (2013); A1;,
Pyridine – Wikipedia,
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