Adding a certain compound to certain chemical reactions, such as: 82257-15-6, 4-Methoxypyridine-3-carboxaldehyde, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, name: 4-Methoxypyridine-3-carboxaldehyde, blongs to pyridine-derivatives compound. name: 4-Methoxypyridine-3-carboxaldehyde
{l-[4-(5-Amino-2-phenyl-pyrimidin-4-ylamino)-phenyl]-cyclobutyl}- carbamic acid tert-butyl ester (0.25 g, 0.58 mmol) was dissolved in acetic acid (30 mL), then 4- methoxy-pyridine-3-carbaldehyde (87.7 mg, 0.64 mmol) and Cu(OAc)2 (105 mg, 0.58 mmol) were added separately. The reaction mixture was stirred at 100 C for 2 h. The reaction mixture was concentrated under reduced pressure, and the residue was dissolved in ethyl acetate (150 mL). The organic layer was washed with aqueous sat. NaHC03 solution, followed by brine, dried over sodium sulfate, filtered and concentrated to give crude desired product (-150 mg), which was used directly without further purification. LC/MS (ESI+): e/z: 549.2 [M+l]+.
The synthetic route of 82257-15-6 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; ARRAY BIOPHARMA INC.; GENENTECH, INC.; SKELTON, Nicholas; GRADL, Stefan; BLAKE, James F.; GRAHAM, James M.; GUNAWARDANA, Indrani W.; HENTEMANN, Martin; MARLOW, Allison L.; TANG, Tony P.; WO2013/78254; (2013); A1;,
Pyridine – Wikipedia,
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