Reference of 885588-12-5, Adding some certain compound to certain chemical reactions, such as: 885588-12-5, name is 2-Bromo-5-fluoro-4-pyridinecarboxylic acid,molecular formula is C6H3BrFNO2, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 885588-12-5.
To a solution of 2-bromo-5-fluoroisonicotinic acid (3.0 g, 13.64 mmol) in EtOH (30 mL) was added EtONa (3.7 g, 54.55 mmol). The reaction was heated at 60 00 for 24 hours then cooled to room temperature and thionyl chloride (3.2 g, 27.28 mmol) added dropwise. Thereaction was stirred at room temperature overnight then the solvent removed. The residue was partitioned between DOM (20 mL) and water (10 mL) and the aqueous phase extracted with DOM (3 x 10 mL). The combined organic extracts were washed with a saturated aqueous NaHCO3 solution (3 x 10 mL), brine (3 x 10 mL), dried (Na2SO4), filtered and concentrated. The residue obtained was purified by column chromatography(EtOAc/petroleum ether=1/20 v/v) to give the title compound (2.1 g, 56%) as an off-white solid. 1H-NMR (400MHz, ODd3) 6 8.14 (s, 1 H), 7.69 (s, 1 H), 4.40-4.35 (q, J = 7.2 Hz, 2H), 4.21-4.15 (q, J= 6.8 Hz, 2H), 1.46 (t, J= 7.2 Hz, 3H), 1.38 (t, J= 7.2 Hz, 3H); LOMS RT2.61 mm; m/z 274, 276 [M+H].
According to the analysis of related databases, 885588-12-5, the application of this compound in the production field has become more and more popular.
Reference:
Patent; CTXT PTY LIMITED; BERGMAN, Ylva Elisabet; CAMERINO, Michelle Ang; STUPPLE, Paul Anthony; (81 pag.)WO2017/153520; (2017); A1;,
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