Application of 89364-04-5, In the chemical reaction process,reaction time,type of solvent,can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product.An updated downstream synthesis route of 89364-04-5 as follows.
2.02 g (10.0 mmol) of 3-bromo-4-nitropyridine,2.20 g (11.0 mmol) of 4-bromophenylboronic acid,0.46 g (0.4 mmol) of tetraphenylphenylphosphine palladium,1.33 g (25 mmol) of Na2CO3 was dissolved in 60 mL of dioxane and 10 mL of water,110 reflux 12h, cooling,Poured into 80mL water,After extraction with 100 mL of ethyl acetate three times,Dried over anhydrous magnesium sulfate.The solvent was removed in vacuo,The solid was subjected to column chromatography,To give 2.1 g of product as a yellow solid (yield: 75%)
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,89364-04-5, its application will become more common.
Reference:
Patent; Zhejiang University; He, Qinggang; Ren, Rong; Zhang, Kai; Zhang, Hong; Tian, Mei; (9 pag.)CN106588915; (2017); A;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem