Adding a certain compound to certain chemical reactions, such as: 13466-38-1, 5-Bromopyridin-2-ol, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, category: pyridine-derivatives, blongs to pyridine-derivatives compound. category: pyridine-derivatives
Step 1 Preparation of Compound a42 (0465) Compound a41 (1.12g, 6.5mmol) was dissolved in 1,4-dioxane (15mL), t- butyl ((1S, 2R) -2- hydroxy-cyclopentyl) carbamate (1.0g 5.0mmol), triphenylphosphine (1.7g, 6.5mmol) and dimethyl oxyethyl azodicarboxylate (1.5g, 6.5mmol) were added and the mixture was stirred at 65C for 1 hour. Water was added to the reaction mixture, and the mixture was extracted with ethyl acetate. The organic layer was washed with saturated brine, and dried over anhydrous magnesium sulfate. The solvent was distilled off under reduced pressure, and the ontained residue was purified by silica gel column chromatography (hexane-ethyl acetate) to give compound a42 (1.4g, 77% yield). 1H NMR (CDCl3) delta: 1.41 (s, 9H), 1.45-1.54 (m, 1H), 1.71-1.85 (m, 3H), 2.10-2.15 (m, 1H), 2.23-2.26 (m, 1H), 3.97 (m, 1H), 4.91 (m, 1H), 5.13-5.14 (m, 1H), 6.67 (d, J = 8.7 Hz, 1H), 7.63 (d, J = 8.7 Hz, 1H), 8.15 (s, 1H). [M + H] = 358.3, Method Condition 4: retention time 2.57 minutes
The synthetic route of 13466-38-1 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; Shionogi & Co., Ltd.; KOBAYASHI, Naotake; ASAHI, Kentarou; TOMIDA, Yutaka; OHDAN, Masahide; FUMOTO, Masataka; SASAKI, Yoshikazu; KURAHASHI, Kana; INOUE, Takatsugu; URABE, Tomomi; NISHIURA, Yuji; IWATSU, Masafumi; MIYAZAKI, Keisuke; OHYABU, Naoki; WADA, Toshihiro; KATOU, Manabu; (276 pag.)EP3059225; (2016); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem