Related Products of 139022-25-6, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 139022-25-6, name is Imidazo[1,2-a]pyridine-6-carboxylic acid, molecular formula is C8H6N2O2, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.
A solution of imidazo[1 ,2-a]pyridine-6-carboxylic acid (0.100 g, 0.62 mmol), 5-(3-chlorobenzyl)pyridin-2-amine (0.161 g, 0.74 mmol), 1 -[b/s(dimethylamino)methylene]- 7/-/-1 ,2,3-triazolo[4,5-b]pyridinium 3-oxid hexafluorophosphate (0.353 g, 0.93 mmol) and A/-A/,A/-diisopropylethylamine (0.240 g, 1 .86 mmol) in A/,A/-dimethylformamide (3 ml_) was stirred at room temperature for 2 h. The crude sample was dissolved in minimal A/,A/-dimethylformamide and purified via prep-HPLC (Boston C18 21 *250 mm 10 pm column; acetonitrile/0.01 % aqueous trifluoroacetic acid) to give A/-(5-(3-chlorobenzyl)pyridin-2-yl)imidazo[1 ,2-a]pyridine-6-carboxamide (0.048 g, 0.1 12 mmol, 18.0%) as a faint yellow solid. 1 H NMR (500 MHz, Dimethylsulfoxide-c/6) d 1 1 .26 (s, 1 H), 9.57 (s, 1 H), 8.41 (d, J = 1 .8 Hz, 1 H), 8.37 (d, J = 2.5 Hz, 1 H), 8.34 (dd, J = 4.8, 4.8Hz, 1 H), 8.22 (d, J = 2.0 Hz, 1 H), 8.12 (d, J = 8.5 Hz, 1 H), 8.02 (d, J = 9.4 Hz, 1 H), 7.77 (dd, J = 8.5, 2.3 Hz, 1 H), 7.36- 7.33 (m, 2H), 7.29-7.25 (m, 2H), 4.00 (s, 2H); LCMS (ESI) m/z: 363.0 [M+H]+.
While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 139022-25-6, Imidazo[1,2-a]pyridine-6-carboxylic acid.
Reference:
Patent; YUMANITY THERAPEUTICS, INC.; LE BOURDONNEC, Bertrand; LUCAS, Matthew; OZBOYA, Kerem; PANDYA, Bhaumik; TARDIFF, Daniel; TIVITMAHAISOON, Parcharee; WRONA, Iwona; (475 pag.)WO2019/183587; (2019); A1;,
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