Share a compound : Methyl 2-chloro-4-iodonicotinate

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,185041-05-8, its application will become more common.

Synthetic Route of 185041-05-8 ,Some common heterocyclic compound, 185041-05-8, molecular formula is C7H5ClINO2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

Containing 4 g of 2-chloro-4-iodo-nicotinate (12.87 mmol) in 50 ml dimethylformamide solution, was added 3.6 g of t-butyl cyanoacetate (25.75 mmol, 2 eq.), 7.1 g potassium carbonate (51.5 mmol, 4 equiv.) and 13 mg of cuprous iodide (0.1 mmol, 0.01 eq.) and the solution was stirred overnight at 50 deg.] C, the solvent is removed to give residue was purified with silica gel column to give the product, 4- (2-tert-butoxy-1-cyano-2-oxoethyl) -2-chloro-nicotinic acid methyl ester (2.8 g, 66% yield).

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,185041-05-8, its application will become more common.

Reference:
Patent; BIOGEN MA INC.; SUNESIS PHARMACEUTICALS, INC.; ARNDT, JOSEPH; CHAN, TIMOTHY; GUCKIAN, KEVIN; KUMARAVEL, GNANASAMBANDAM; LEE, WEN-CHERNG; LIN, EDWARD YIN-SHIANG; SCOTT, DANIEL; SUN, LIHONG; THOMAS, JERMAINE; VAN VLOTEN, KURT; WANG, DEPING; ZHANG, LEI; ERLANSON, DANIEL; (469 pag.)TWI525093; (2016); B;,
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