Reference of 16135-36-7, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.16135-36-7, name is Methyl 4-aminonicotinate, molecular formula is C7H8N2O2, molecular weight is 152.15, as common compound, the synthetic route is as follows.
4- [2-(5-Chloro-2-fluoro-phenyl)-7-(2-dimethylamino-ethylamino)-pyrido [2,3-d] – pyrimidin-4-ylamino] -nicotinic acid methyl ester. Crude imino halide, N’-[4-Chloro-2-(5-chloro-2-fluoro-phenyl)-pyrido[2,3-d]pyrimidin-7-yl]-N,N- dimethyl-ethane-l,2-diamine (0.58 g) dissolved in dioxane (80ml) was added Pd(OAc)2 (0.077 g) followed by BINAP (0.115 g), 4-amino-pyridyl-3-carboxylate (0.232 g) and Cs2CO3 (0.748 g). The reaction mixture was heated to 8O0C for 15h. The reaction mixture was cooled to r.t. and filtered through Celite and the crude material was purified by silica gel flash column chromatography (3:2/ethyl acetate:hexane) to give 4-[2-(5-Chloro-2-fluoro-phenyl)-7-(2-dimethylamino-ethylamino)-pyrido[2,3-d]- pyrimidin-4-ylamino] -nicotinic acid methyl ester (0.300 g).
The chemical industry reduces the impact on the environment during synthesis 16135-36-7, I believe this compound will play a more active role in future production and life.
Reference:
Patent; TIBOTEC PHARMACEUTICALS LTD; WO2006/100310; (2006); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem