Related Products of 29681-43-4, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.29681-43-4, name is Methyl 4-methoxypyridine-2-carboxylate, molecular formula is C8H9NO3, molecular weight is 167.16, as common compound, the synthetic route is as follows.
b) Lithium aluminum hydride (16 ml of a 1.0 N solution in diethyl ether, 16 mmol) was added to a solution of methyl 4-methoxypicoline-2-carboxylate (2.70 g, 16 mmol) in diethyl ether (50 ml) at ambient temperature. The reaction was stirred for 1 hour, poured into an aqueous solution of Rochelle’s salt (250 ml) and the reaction mixture extracted with ethyl acetate (3*50 ml). Purification of the crude product by flash chromatography on silica gel, eluding with dichloromethane-ethyl acetate, yielded 2-(hydroxymethyl)-4-methoxypyridine (800 mg, 36% yield) as a white solid.
The chemical industry reduces the impact on the environment during synthesis 29681-43-4, I believe this compound will play a more active role in future production and life.
Reference:
Patent; AstraZeneca AB; US7081461; (2006); B1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem