Reference of 1210419-26-3, Adding some certain compound to certain chemical reactions, such as: 1210419-26-3, name is Methyl 6-bromo-5-fluoropicolinate,molecular formula is C7H5BrFNO2, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 1210419-26-3.
Synthesis of methyl 6-(2,6-difluoro-4-(4-hvdroxytetrahvdro-2H-pyran-4-yl)phenyl)-5- fluoropicolinate Method 1 was followed using methyl 6-bromo-5-fluoropicolinate (1.0 equiv.) and 4-(3,5-difluoro-4-(4,4,5,5-tetramethyl-l ,3,2-dioxaborolan-2-yl)phenyl)tetrahydro-2H- pyran-4-ol (1.8 equiv.) at 100 C for 20 min in microwave to give methyl 6-(2,6-difluoro- 4-(4-hydroxytetrahydro-2H-pyran-4-yl)phenyl)-5-fluoropicolinate. LC/MS = 368.0 (MH+), R, = 0.75 min.
According to the analysis of related databases, 1210419-26-3, the application of this compound in the production field has become more and more popular.
Reference:
Patent; NOVARTIS AG; BURGER, Matthew; NISHIGUCHI, Gisele; RICO, Alice; SIMMONS, Robert Lowell; TAMEZ, JR., Victoriano; TANNER, Huw; WAN, Lifeng; WO2014/33631; (2014); A1;,
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