Share a compound : N-(6-Chloropyridin-2-yl)pivalamide

According to the analysis of related databases, 86847-84-9, the application of this compound in the production field has become more and more popular.

Electric Literature of 86847-84-9, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 86847-84-9, name is N-(6-Chloropyridin-2-yl)pivalamide, molecular formula is C10H13ClN2O, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

Preparation 10 : N-(6-Chloro-3 propionamide; To a dry solution of N-(6-chloropyridin-2-yl)-2,2-dimethyl propionamide (Preparation 9, 8.0g, 37.6mmol) in THF (12OmL), cooled to -780C, was added dropwise, a solution of tert- butyllithium in pentane (1.7M, 48.7mL, 82.8mmol) over 40min. The reaction was stirred at -780C for 3h before adding a solution of iodine (11.46g, 45.1mmol) in THF (4OmL) dropwise. The mixture was EPO brought up to rt and stirred for 16h. 2M HCl (3OmL) was added to the reaction, and after 20min the solvent was removed in vacuo. Crude material was partitioned between EtOAc (20OmL) and water (15OmL). Organics were separated and washed with 10% sodium thiosulfate solution (4xl00mL) then NaHCO3 solution (2xl00mL), dried (MgSO4) and the solvent removed in vacuo. The residue was purified by column chromatography (SiO2, CH2Cl2) to give the title compound, m/z (ES+) = 338.93 [M+ H]+.

According to the analysis of related databases, 86847-84-9, the application of this compound in the production field has become more and more popular.

Reference:
Patent; PROSIDION LIMITED; WO2006/59164; (2006); A2;,
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